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If the animal is responsive to a bolus of the agent, a CRI is begunto deliver a background of analgesic drug. The PBL were further fractionated into monocytes, B-cells, and T cells.The melanoma patients, through the study of their lesions were diagnosed/classified as havingeither primary (Stage I) or metastatic (Stage II or greater) melanoma (Clark 1986) The PBL were further fractionated into monocytes, B-cells, and T cells.The melanoma patients, through the study of their lesions were diagnosed/classified as havingeither primary (Stage I) or metastatic (Stage II or greater) melanoma (Clark 1986). The antitumor activity of MI-77301was more pronounced in a set of wild type p53 xenograft models than MI-773,including SJSA-1 osteosarcoma, human prostate, melanoma, colorectal tumor,LNCAP human prostate tumor and human acute lymphoblastic leukemia(WO2012065022), although there is a less pronounced difference between the twocompounds in vitro cell-based cytotoxicity assays.
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